Product details

Zuplenz belongs to a group of drugs known as antiemetics. Doctors frequently prescribe Zuplenz to patients who are going through chemotherapy, radiation, or another cancer treatment and are experiencing associated nausea and vomiting. It’s also taken by patients who have had a recent surgery that is causing heavy nausea.

However, Zuplenz does more than provide nausea relief, although this is a major benefit. Zuplenz can help treat migraine headaches and keep them from forming to their full strength. Taken at the onset of a migraine, Zuplenz may be able to help you conquer your migraine pain and live a pain-free life. If you have suffered from migraines throughout the years, know that it doesn’t have to be this way forever. With Zuplenz or its generic equivalent, Ondansetron, you no longer have to come second to your migraines. At Nurx™, we don’t carry Zuplenz itself, but we do prescribe Ondansetron.

Additional Details

  • Relieves nausea
  • Helps prevent or reduce the severity of migraine headaches
  • Can reduce the instances of vomiting
Active Ingredients
  • Ondansetron base
  • Do not take if you have an irregular heartbeat.
  • Do not take if you have had recent abdominal surgery.
  • Do not take if you have any liver problems.
  • Do not take if your family has a history of sudden cardiac death.
  • Not suitable for children less than 4 years of age.





  • How Does Zuplenz Work?

    Have you been suffering from migraines and just resigned yourself to them as a normal part of your life? The good news is that there is a way to find relief. While Zuplenz is typically prescribed to patients who experience frequent nausea as a result of cancer treatments or surgery, it can also help prevent migraines or reduce their symptoms by blocking serotonin.

  • Is Zuplenz Easy to Get?

    Zuplenz is a common prescription, meaning it's available at most pharmacies, and if you don't have insurance, that's okay too. At Nurx, we want to make high-quality healthcare more accessible and affordable for everyone, so our prices are reasonable and won't break the bank. If you don't have a general practitioner, Nurx can still help get you the medication you need to feel better fast.

    If you do have insurance, great! We'll work with your insurance to get your claim processed for your prescription medication. Contact us to get information on pricing so that you know exactly what to expect.

  • Are There Any Precautions I Should Take When Using Zuplenz?

    Before you take Zuplenz, let your doctor know about any allergies you have, especially if you're allergic to the active ingredient, Ondansetron. Your doctor needs to know about your allergies because Zuplenz may contain inactive ingredients that could cause an allergic reaction.

    You should also tell your doctor if you have experienced an irregular heartbeat, stomach or intestinal problems, or heart problems such as a QT prolongation in the EKG or if anyone in your family has had a sudden cardiac death. If you have low potassium or magnesium in your blood, you may be at an increased risk for QT prolongation, especially if you are on a diuretic.

    Because Zuplenz may make you dizzy or drowsy, refrain from driving or using heavy machinery until you know how the medication affects you. Alcohol can increase the effects of Zuplenz, so avoid alcoholic beverages while on this drug.

    Let your doctor know if you're pregnant or breastfeeding. Zuplenz may not be considered safe for your particular situation, or your doctor may want to give you a smaller dosage instead.

  • Are There Any Possible Side Effects?

    Any medication can bring about side effects. It's essential to be aware of the possible side effects so that you know what's common versus what's a cause for concern. The great news about Zuplenz, and the reason we love this medication, is that there aren't many serious side effects.

    The most common side effects of Zuplenz and its generic equivalent include:






    There are also some more serious but less likely side effects, such as:

    Abdominal pain.

    Muscle spasms.

    Muscle stiffness.


    Chest pain.

    Irregular heartbeat, including a faster or slower than normal heartbeat.


    Fever with no known origin.

    Severe diarrhea.

    Loss of coordination.

    Twitching muscles.

    If you experience any of these side effects, reach out to your doctor right away.

    You may not know you're allergic to this medication until you start developing an allergic reaction. Be on the lookout for swelling of the lips, tongue, or throat, hives, a rash, difficulty breathing, severe dizziness, or itching in or around your mouth.

  • Does Zuplenz Interact With Other Drugs?

    Like other drugs, Zuplenz can interact with other medications, so it's important to discuss any medications you're taking with your doctor. This includes all other prescriptions, over-the-counter medicines, vitamins, supplements, and herbs. Depending on what you're taking, you may have an increased risk for more serious side effects.

    Make sure your doctor knows if you are taking apomorphine, tramadol, diuretics, or any drugs that have the potential of affecting your heart rhythm. Because Zuplenz affects your serotonin levels, it's also important to know if any of your medications increase serotonin. When you're on more than one medication that does this, you can experience serotonin syndrome or toxicity. Specific drugs that increase serotonin levels include St. John's wort, the street drug MDMA, and some antidepressants or SSRIs.

  • How Do I Get a Prescription for Zuplenz Through Nurx?

    It's simple to get a prescription for the generic equivalent of Zuplenz, Ondansetron, through Nurx. Simply complete our medical assessment online to provide our physicians with your medical history. Then, answer any questions the doctor may have, and they can get to work on creating a personalized treatment plan for the medication you need.

    There's a $60 annual fee that's not covered by your insurance for the Nurx consultation for Headache and Migraine Treatment. This is an upfront fee that we charge when you complete your initial medical evaluation.

  • Can I Buy This Drug Online Through Nurx?

    We don't carry Zuplenz at Nurx, but we do have its generic equivalent, Ondansetron. All you have to do is complete our medical assessment and speak with a physician about your medical history and the symptoms you're experiencing. Then, our Nurx providers (who are approved in your state) can prescribe Ondansetron if they believe that you're a good candidate for the medication. We know you want to manage your migraine as soon as possible and are committed to getting you the medication you need at a price you can afford.

  • How Long Would It Take to Deliver This Drug If I Bought It Online?

    Get ready to say goodbye to migraine pain in no time at all! Once our medical team reviews your prescription request and our pharmacy fills the prescription, it will take 3-5 business days to ship your medication right to your door. We use one- to three-day priority shipping through USPS, at no cost to you, so you'll have your prescription right away.

  • Is There a Generic Version of Zuplenz?

    Yes, the generic version of Zuplenz is Ondansetron, and it's what our doctors at Nurx prescribe.

  • Who Makes Zuplenz?

    Zuplenz is manufactured by SELLAS Life Sciences Group Inc., a biopharmaceutical company based in New York.

  • How Long Does Zuplenz Stay in Your System?

    Zuplenz, when used correctly, should stay in your system for about eight hours. You should feel the most relief two hours into taking a dose.

  • How Long Does Zuplenz Take to Work?

    Zuplenz is designed to provide much-needed relief from your painful migraines and associated symptoms of nausea and vomiting. So, it doesn't take long to work. In as little as 30 minutes, you should feel some relief, with the drug hitting its peak effects around the two-hour mark after taking the medication as prescribed.

  • Will Zuplenz Make You Sleepy?

    Tiredness is a possible side effect of Zuplenz, but you may not even experience it. If you do, it should be mild. If you feel that your tiredness is not normal, make sure to contact your doctor.

  • How Does Nurx Work?

    Nurx is a telehealth platform offering easy online access to doctors and seamless delivery of medications. No more time-consuming trips to the clinic and no more frantic pharmacy runs. We put you in control of your own health, empowering you to get the care you need, when you need it. From diagnosis to delivery of prescriptions, we make every part of getting healthy and staying healthy, better.For more information and to sign up, visit www.nurx.com and follow us @nurxapp on Twitter and Instagram.

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