Adapalene Gel .3% (Differin) Image

Adapalene Gel .3% (Differin)

Adapalene Gel .3% (Differin) Image

Product details

Get smooth, unblemished skin with Adapalene, a treatment gel that belongs to a class of medications known as retinoids.

Retinoids affect cell growth and help decrease the formation of pimples while promoting faster healing of existing ones. Retinoids also have an anti-inflammatory effect that decreases swelling and inflammation related to acne breakouts.

Adapalene is available as a gel, cream, or liquid solution. 

Medication type:

Recommended for:

✓ Reducing visible signs of aging

✓ Evening skin texture

✓ Reducing clogged pores

✓ Reducing hyperpigmentation


Price with InsuranceOut-of-Pocket Price
Not availableAs little as $30 per month for the medication


We also charge a $15 medication consultation, which includes unlimited access to our medical team for a full year.

Brand name:


Related products:
Tretinoin Anti-Aging Cream 0.1%


For our refund and return policy, please see our terms of use.

Additional Details

  • Acne treatment
  • Minimizes swelling and inflammation
  • Decreases severity of pimples
  • Reduces number of pimples
  • Retinoid
  • Noncomedogenic
  • Cell renewal
  • Topical gel
  • Heals pimples
Active Ingredients
  • Adapalene USP 0.1%
  • Consult a doctor if pregnant or breastfeeding.
  • Minimize UV light exposure while taking.
  • Do not apply to cuts, abrasions, or sunburned skin.
  • Do not wax treated area.
  • Do not use with astringents, exfoliants, or abrasive soaps and cleaners.
  • Do not use tanning beds while using Adapalene.





  • How it Works

    Adapalene helps to control the formation of new acne breakouts and speed the healing of existing pimples. However, it is not a cure for acne and must be used continuously to control this condition. During the first 8 to 12 weeks of use, Adapalene may cause acne to worsen, as it brings existing pimples to the surface to begin the healing process. It is important to continue using Adapalene for several months to assess the full potential of this medication.

    You should follow the directions on the packaging exactly for any Adapalene product unless otherwise directed by your doctor. Do not attempt to increase or reduce usage without first contacting your healthcare provider.

  • Availability

    Adapalene is available over the counter. You can find it in many pharmacies and big-box stores. Adapalene is the generic name for Differin acne treatment gel. Other manufacturers may also offer products that use Adapalene as the active ingredient, such as La Roche-Posay Effaclar Adapalene Gel or ProactivMD Adapalene Gel Acne Treatment. If you get a prescription for Adapalene from your doctor, your insurance may cover some of the cost, depending on your plan and coverage. You can typically expect to pay around $17 for a 0.5-ounce tube of Adapalene gel.

  • Precautions

    Many skin care products can cause irritation if used along with Adapalene, so it's best to discuss all products you're using with a doctor or pharmacist before you add Adapalene to your skin care regimen. You will likely experience a reaction if you use Adapalene with skin care products that contain:

    • Alcohol.
    • Lime rind.
    • Sulfur.
    • Salicylic acid.
    • Glycolic acid.
    • Alpha hydroxy acid.
    • Spices.

    You should avoid any unnecessary exposure to sunlight while using Adapalene. Wear protective clothing that covers as much skin as possible, and always use a sunscreen with an SPF of 15 or higher. Exposure to cold or wind may cause irritation when you're taking Adapalene. Avoid exposure to tanning beds or other forms of artificial light. You should not use hot wax for hair removal while you're using Adapalene. 

    When using Adapalene, you should avoid contact with the eyes, nose, lips, and mucous membranes. 

    The effectiveness of Adapalene has not been assessed for patients under the age of 12 or over the age of 65.

  • Side Effects

    Side effects associated with Adapalene are usually worst during the first month of treatment and will typically lessen with time. The most common effects are:

    • Stinging or burning.
    • Scaling.
    • Dry skin.
    • Erythema (redness).

    Using a moisturizer will typically reduce the severity of these side effects. 

    Other common side effects include:

    • Itching.
    • Sunburn.
    • Peeling.
    • Brief warming sensation after application.

    Less common side effects that may occur with Adapalene are:

    • Eczema.
    • Rash.
    • Acne flare.
    • Contact dermatitis.

    Serious but uncommon side effects may include:

    • Intense burning.
    • Eyelid swelling.
    • Skin discoloration.
    • Red, watering eyes.
    • Very irritated or red skin.

    If you experience serious side effects with Adapalene or have any form of irritation that is too severe to manage, you should consult your healthcare provider. Your doctor may recommend that you reduce the frequency of use or discontinue using Adapalene entirely.

  • Important Information

    There are no known drug interactions with Adapalene. As mentioned previously, you may need to change your skin care routine if you use abrasive products or those that dry out your skin. You should not use Adapalene products if you have had severe adverse reactions to Adapalene in the past. This medication is for topical use only. If ingested, you should seek medical help or contact a Poison Control Center immediately.

  • Can I Buy This Drug Online Through Nurx?

    No, this medication is not available from Nurx.

  • Who Makes This Drug?

    The brand name version of Adapalene is Differin. This is a product of Galderma, the medical solutions branch of Nestle Skin Health.

  • How long does it take to see results from Adapalene?

    Adapalene may cause your acne to worsen before it improves. This is because the retinoid brings pimples and imperfections to the surface. Since pimples can take four to six weeks to form, you may have developing breakouts under the surface of your skin that weren't visible when you began using Adapalene. After about a month of continuous use, you may begin to see results. However, some patients will not see notable results until they've used Adapalene daily for three months.

  • What happens when you stop using Adapalene?

    If you discontinue the use of Adapalene before it has a chance to work properly, your acne may worsen. It's best to discuss your skin care with a healthcare provider before you choose to stop using Adapalene to determine if a different frequency or concentration will give you better results.

  • Does Adapalene remove dark spots?

    Adapalene has been used by some as an anti-aging product. There is some evidence that it can help reduce the appearance of dark spots. Adapalene may also help reduce the appearance of fine lines and brighten dull skin. If you plan to use Adapalene for purposes other than acne control, you should speak with your healthcare provider about the best way to incorporate this product into your skin care routine.

  • Can I use Adapalene every day?

    Yes, you should use Adapalene daily to get the best results from this skin care product. You should apply Adapalene before bed, so you don't need to apply makeup or other products on top of the Adapalene medication. Unless otherwise advised, the best method of application is to:

    1. Gently cleanse your skin with a mild soap. Do not scrub vigorously, as this can irritate the skin and worsen sensitivities that are already caused by Adapalene. Pat dry with a soft clean towel.
    2. Gently spread a thin layer of Adapalene gel or cream over the affected area. If you're using Adapalene on a wipe, open the packet and gently wipe the affected area. Discard Adapalene wipes after use. These are not intended for reuse. Apply Adapalene to the entire area that's affected rather than a single pimple or small patch of irritation.
    3. Apply a moisturizer to the affected area if needed to calm irritation and dryness. This is optional.

  • How Nurx Works

    Nurx is a telehealth platform offering easy online access to doctors and seamless delivery of medications. No more time-consuming trips to the clinic and no more frantic pharmacy runs. We put you in control of your own health, empowering you to get the care you need, when you need it. From diagnosis to delivery of prescriptions, we make every part of getting healthy and staying healthy, better. 

    For more information and to signup, visit and follow us @nurxapp on Twitter and Instagram.

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