Rx

Tretinoin cream .025%

Tretinoin exfoliates skin to reduce dark spots caused by melasma.

Dark spots/Melasma Icon Dark spots/Melasma
Topical cream Icon Topical cream

$30/month

Medication shipped and billed every 3 months. One bottle of medication contains a 3-month supply. Medication costs vary based on prescribed treatment and applicable insurance coverage. Not all insurance plans are accepted. Additional costs apply, including a consultation and support fee.
This treatment requires an online consultation with a Nurx medical provider. If prescribed, they'll check in to ensure your treatment is working.

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How tretinoin cream treats melasma*

  • Reduces dark spots caused by melasma
  • Reduces hyperpigmentation and uneven pigmentation
  • Reduces signs of skin aging related to sun exposure
Find my treatment
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DID YOU KNOW?

20x stronger

Tretinoin is 20x stronger than over-the-counter retinols

Real patient stories

The science behind it

Fact 01

Fades hyperpigmentation and melasma

Tretinoin gently exfoliates skin to reduce the appearance of dark spots.

Fact 02

Stimulates collagen production

By increasing skin's cellular turnover, tretinoin boosts collagen production.

Fact 03

Visible results over time

Generally, it takes about six weeks to start seeing results like a more even skin tone.*

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How to use tretinoin

Consistency is key to maximizing the effectiveness of your melasma treatment.

Drug facts

Tip 1

Apply once a day (we recommend applying after you wash your face in the morning and at night).

Tip 2

Before sun exposure, apply sunscreen as tretinoin can make skin more sensitive to the sun.

Tip 3

If you have sensitive skin, try applying tretinoin just once or twice a week, and then work up to more frequency as your skin adjusts.

How Nurx works

1

Request treatment

Complete our online medical consultation, which asks questions about your health history and skin concerns.

2

Connect with a provider

After evaluating your consultation, a provider licensed in your state will prescribe treatment (if clinically appropriate).

3

Get it delivered

We’ll send a 3-month supply to your doorstep and check in with you to see how it’s working. Pause or cancel anytime.

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100%

online expert-level care

2+ million

Nurx patients served

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Why Nurx?

Affordable

Affordable out of pocket pricing

Convenient

Free shipping & pause or cancel anytime

Personalized

Providers help you find the right treatment

Supportive

Unlimited messaging for any questions, anytime

Common questions

  • How do I use tretinoin?

    Tretinoin should be used once daily at bedtime. To use tretinoin cream, simply wash your face with a mild facial cleanser. Make sure your skin is dry before using the product. Then, take a pea-sized amount of tretinoin and apply a thin layer to your skin. We recommend following up with a layer of moisturizer, especially if you have dry or acne-prone skin.

    Tretinoin can make your skin more sensitive to UV light. Using tretinoin at night lowers your risk of sun sensitivity. During the daylight hours, protect your skin from sunburn and sun damage by wearing protective clothing, hats, and sunscreen with an SPF of 30 or higher.

    Avoid getting tretinoin in your eyes, ears, mouth, and nose. Tretinoin should be stored tightly closed, at room temperature, in its original container.

  • How long does tretinoin take to work?

    If you are new to tretinoin, you may experience some skin flaking and if acne prone, some acne flares in the first few weeks.This is a normal part of the skin renewal process. Don't give up! Most people see a noticeable improvement in their complexion after using tretinoin for 6 to 12 weeks.

  • How often should I use tretinoin?

    Tretinoin should be applied once daily at bedtime. It should not be used during the day as it can be deactivated by sunlight.

  • Does tretinoin help with wrinkles?

    Because it speeds up cell turnover, tretinoin can improve fine lines, wrinkles, and skin texture. Tretinoin also increases your skin's production of collagen, a vital component in young, healthy skin.

  • Does tretinoin have any known side effects?

    Like every topical retinoid, tretinoin use may cause side effects. Most of the side effects caused by tretinoin are mild and include redness, dryness, flaking, or peeling skin. These effects can be managed by using more moisturizer and using the medication less frequently such as every other night when first starting. You may also experience a mild, temporary stinging or warming sensation when applying tretinoin. Skin treated with tretinoin is more prone to sunburn. Most people using tretinoin find that side effects lessen as their skin adjusts to treatment. These mild side effects generally dissipate when tretinoin is no longer used.

  • What precautions should I take when using tretinoin?

    As with any prescription medication, discuss your medications, allergies, and treatment options with your primary care doctor or a Nurx provider before using tretinoin cream. If your skin is irritated or sunburned, you may need to allow your skin to heal before beginning treatment. Your medical provider can advise you when to add tretinoin to your skin care regimen.

    When using tretinoin, your facial cleansers and cosmetics should be gentle, non-abrasive, and non-drying. Confused about which products to use? Your Nurx provider can help you choose products that maximize the benefits of tretinoin and minimize unpleasant side effects.

    Tretinoin should not be used by patients who are pregnant, breastfeeding, or trying to conceive. If this applies to you, your provider may help you find an alternative treatment that is appropriate for you.

  • Can I use tretinoin cream with other medications?

    Tretinoin is generally compatible with other medications. Using tretinoin with sulfur based washes, salicylic acid, alpha hydroxy acids, glycolic acid, or resorcinol may cause increased dryness. Using tretinoin at the same time of day as benzoyl peroxide may diminish tretinoin's effectiveness and increase dryness.

  • Does tretinoin expire?

    All prescription retinoids come with an expiration date that can be found on the medication’s packaging. Although not dangerous to use, expired tretinoin may be less effective.

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DR. PETER YOUNG, MEDICAL DIRECTOR

Meet your medical team

Peter Young, MD is the Medical Director for Nurx’s Dermatology specialty. Dr. Young is a board-certified dermatologist who advises the Nurx medical team on how to provide the highest quality of care for dermatology conditions through telehealth.

†Tretinoin Cream 0.025%, Rx only, treats acne, hyperpigmentation, and palliation of fine lines. Tretinoin may cause side effects, including skin peeling, flaking, and irritation. If you would like to learn more about Tretinoin, please see the full prescription information, here. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch: HTTPS://WWW.FDA.GOV/SAFETY/MEDWATCH or call 1-800-FDA-1088.
*Individual results may vary.
‡The information provided here is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely upon the content provided here for specific medical advice. If you have any questions or concerns, please talk to your provider.
◊Services not offered in every state. Medications prescribed only if clinically appropriate, based on completion of the required consultation.

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