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Nortriptyline (brand name Pamelor) is an antidepressant medication that belongs to the tricyclic antidepressant class. It was approved by the FDA in 1980 and has been prescribed ever since as a treatment for major depressive disorder (MDD) and other conditions. Nortriptyline functions similarly to other tricyclic antidepressants by increasing levels of serotonin, norepinephrine, and other neurotransmitters in the brain.
Medication strengths (in stock):
10 MG, 25 MG, 50 MG
✓ Relieving symptoms of depression
✓ Treating migraines
|Price with Insurance||Out-of-Pocket Price|
|As little as $0 per month for the medication||As little as $25 per month for the medication|
Ongoing medication management costs $55/month
What is nortriptyline?
Nortriptyline (Pamelor) is a tricyclic antidepressant (TCA) used to treat depression. Some people may use it to treat other conditions, including migraine headaches and nerve pain. Nortriptyline affects chemicals in the brain that may become unbalanced and cause depression.
How does nortriptyline work?
Nortriptyline, also known as Pamelor, belongs to a class of drugs called tricyclic antidepressants. The drug blocks norepinephrine and serotonin reuptake (SNRIs such as venlafaxine may produce similar effects). By preventing reuptake, more of these neurotransmitters remain active in their receptors for longer periods of time, which helps boost mood.
What are the side effects of nortriptyline?
One of the most common side effects is dry mouth. Some people experience headaches, dizziness and/or drowsiness as a result of taking nortriptyline. These side effects are typically mild. If these side effects are persistent or become more severe contact your provider.
How do I take nortriptyline?
Nortriptyline is usually taken orally once a day before bed. Always take your dose as prescribed by your provider. Your provider may start you on a low dose of nortriptyline and gradually increase the dose. Do not increase or decrease your daily dosage without first consulting your provider.
Can I take nortriptyline with other medications?
Nortriptyline can be taken with other medications and may be used as part of a combination therapy with other medications to treat depression. However, nortriptyline may interact with other medications, including MAOIs, SSRIs, and anticholinergic medications. Always consult your provider before taking two medicines at once, and tell your provider about any medications or supplements you’re currently taking before starting nortriptyline.
Are there any risks when taking nortriptyline?
It's always a good idea to tell your provider if you're taking any other medications while on Nortriptyline, and be sure to let them know if you start or stop any medications during treatment. Although Nortriptyline isn't thought to cause serious interactions, it can still affect how other drugs work in your body. If you're on any blood thinners such as warfarin (Coumadin), for example, it may affect how much blood-thinning medication your body needs. Also, nortriptyline can cause drowsiness when taken with alcohol. If you’re planning on drinking while on an antidepressant, talk to your provider beforehand about how to take it safely.
How quickly does nortriptyline work?
You may start to feel better within two weeks of beginning nortriptyline. It typically takes between two to six weeks before you feel the full benefits of taking nortriptyline. Do not stop taking nortriptyline suddenly, even if you feel it is not helping your symptoms. If nortriptyline does not appear to be helping after six weeks, contact your provider.
How does Nurx work?
Nurx is a telehealth platform offering easy online access to doctors and seamless delivery of medications. No more time-consuming trips to the clinic and no more frantic pharmacy runs. We put you in control of your own health, empowering you to get the care you need, when you need it. From diagnosis to delivery of prescriptions, we make every part of getting healthy and staying healthy, better.
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