Rx

Oral medication plan

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Discover the daily weight management treatment plan that may be right for your weight goals.*◊ This plan may include bupropion, naltrexone, metformin,|| and/or topiramate.

Weight loss
Pill

Starts at $60/month

as low as $0/month with insurance

Medication cost may vary based on prescribed treatment and applicable insurance coverage, price not guaranteed. Not all insurance plans are accepted. Medication shipped and billed monthly. Additional costs apply, including consultation, ongoing care, side effect management, and applicable treatment plan updates.

Daily oral medications: Know the basics

  • Each medication works with a different part of the brain to support weight loss
  • Generally, these medications help reduce appetite and cravings
  • Medications like topiramate also help improve impulse control
  • Prescribed (if appropriate) as medication plans, combining multiple treatments for optimal results
Find my treatment

Get to know the treatment options

If appropriate, patients will be prescribed a combination of medications, starting with naltrexone and bupropion. Studies have shown that combining these medications is more effective for weight loss than using either medication alone. Additional medications can be added, if needed, to help you reach your goals. Your provider will share instructions on how to appropriately take these medications together.

starter treatment

Bupropion

Bupropion reduces appetite and cravings by affecting the neurotransmitters dopamine and norepinephrine. It may also help your body burn more calories. 

starter treatment

Naltrexone

Naltrexone is thought to target the brain’s reward system to reduce cravings and increase feelings of fullness.

add-on treatment

Metformin

Metformin, which is used as a treatment for type 2 diabetes and prediabetes, helps your body use sugar more effectively and decrease appetite. 

add-on treatment

Topiramate

Topiramate works by regulating signals in the brain that affect the appetite to increase feelings of fullness and reduce how much you eat.

How to use your treatment plan§

What to expect

Each of these medications can cause side effects, so it’s recommended to start with a low dose and gradually increase it over time to reach the target dose.

Your provider may even recommend adding new medications to your plan to support your progress.

Always follow your provider’s exact prescribing instructions.

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Nurx patients served

How Nurx works

1

Request treatment

Complete our online consultation, which
asks questions about your health history,
weight goals, and medication preferences.

2

Connect with a provider

After evaluating your consultation, a
provider licensed in your state will prescribe
a weight management treatment plan
(if clinically appropriate).

3

Get it delivered

We’ll send your prescription straight to your doorstep and check in with you to see how it’s working. You can reach out to your medical provider and adjust, pause, or cancel your treatment plan anytime.

4

Receive ongoing care

You’ll get support with progress tracking, educational content around healthy diet
and exercise, and appropriate treatment adjustments. We’ll also provide tips and 
treatment options for side effect management.

Why Nurx?

Affordable

Safe, quality treatment at an attainable price with or without insurance

Convenient

Easy refills & free shipping to your door; pause or cancel anytime

Personalized

Providers with expertise in women’s health help you find the right treatment

Supportive

Unlimited messaging for questions, treatment adjustments, and side effect support

Common questions§

  • What are the oral weight management treatment plan options?

    If prescribed, most patients will start with bupropion and Naltrexone as the foundation of their oral weight Management treatment plan. If appropriate, your provider may also recommend adding metformin and/or topiramate to your treatment plan.

  • How long do I need to take these medications before  I see weight loss?

    You may notice a change in your weight in the first few months of treatment. However, for most people, it can take a few months to notice a change in weight. Consistency is key! Taking the medications, eating a healthy diet, and incorporating physical activity into your lifestyle are all crucial steps to achieving results. 

  • How can I make these medications work best for me? 

    Bupropion and Naltrexone are not magic. To get the best results with these medications, you need to combine them with a healthy diet and regular exercise. It’s also important to have regular check-ins with your Nurx provider to track your progress and adjust your treatment if needed.

  • Do these medications have any known side effects?

    The most common side effects of bupropion and naltrexone include nausea, constipation, headache, vomiting, dizziness, insomnia, anxiety and dry mouth. Although rare, serious side effects may occur including seizures, suicidal thoughts, opiate overdose (if taken WITH opioids), increases in blood pressure, liver toxicity, and angle-closure glaucoma.

    The most common side effects of metformin are diarrhea, nausea, vomiting, flatulence, abdominal discomfort, loss of appetite, and metallic taste. Rarely, metformin can cause  lactic acidosis, a life-threatening medical emergency that may lead to death and requires hospital treatment. Symptoms of lactic acidosis may include tiredness, weakness, nausea, vomiting, stomach pain, decreased appetite, rapid breathing, dizziness, muscle pain, or feeling cold in your hands or feet. If you experience these symptoms, stop taking metformin and seek medical care immediately. Most people with lactic acidosis with metformin have other conditions that, combined with metformin, lead to lactic acidosis.

    The most common side effects of topiramate include somnolence (feeling tired), difficulty concentrating, tingling sensations, dizziness, difficulty sleeping, and depression. Although rare, serious side effects may occur including metabolic acidosis, kidney stones, decreased sweating leading to hyperthermia, and acute angle-closure glaucoma.

    We are here to help you manage side effects. If you experience side effects, be sure to let your provider know as they can provide personalized guidance and educational content. They may even be able to prescribe treatment to help you manage these concerns.

    For any serious or severe side effects, please seek immediate in-person medical care.

  • What precautions should I take when using these medications?

    It's important to have open and honest communication with your healthcare provider before taking any medication, especially if you have certain health conditions or if you are taking other medications. Be sure to talk to your healthcare provider before starting these medications if you have depression, other mental illness, diabetes, or are 65 years or older.  

       
    • Bupropion may cause changes in your mood or behavior. Stop taking Bupropion and let your healthcare provider know immediately if you develop agitation, hostility, depressed mood, or changes in thinking/behavior that are not typical for you.
    •     
    • Naltrexone can increase the risk of an opioid overdose if you take opioid medications while using it. Do not take this medication if there is a chance you will take opioid pain medication. This medication may increase your blood pressure or cause hypertension. Do not start this medication if you have been diagnosed with coronary artery disease. 
    • Metformin is safe for most people. However, you should get metformin from an in-person provider if you have liver or kidney disease, heart failure, low blood pressure, alcohol dependence, or a history of lactic acidosis. Do not take this medication if you are pregnant, breastfeeding, or plan to become pregnant. Additionally, metformin is safe to use with most medications but it's a good idea to talk to your primary care provider before combining metformin with fenofibrate or colchicine as the combination may increase your risk for muscle damage. Additionally, medication such as topiramate, zonisamide, and valproic acid may increase the risk of lactic acidosis.
    • Topiramate is safe for most people. However, you SHOULD NOT take topiramate if you have kidney or liver disease, history of glaucoma, history of kidney stones, serious depression. If you have history of depression and/or suicide, reach out to your care provider before starting topiramate. Do NOT get pregnant or breastfeed while taking this medication, as studies show that it can be associated with birth defects. Additionally, topiramate may cause your birth control to be less effective. We recommend touching base with your provider to discuss alternatives and/or strategies to prevent pregnancy while using this.

  • How much does the program cost?

    The medical consult fee is a one time charge of $39. Patients will also be charged an ongoing care fee of $59/month. If you are prescribed oral medication, you may be able to use insurance. If you use cash, your treatment plan will cost $60-105/month depending on your medications. 

Hayley Miller, MD

Meet your medical team

“Each individual will have a unique experience with weight loss treatment. Our team is here to support each step of your journey to make sure you have everything you need to succeed.”

Dr. Miller is the Medical Director of Nurx Weight Management, advising Nurx’s medical team to provide the highest quality of care to help patients achieve their weight loss goals.

Talk to our experts

Not sure if this medication is right for you?

Connect with a Nurx provider for a personalized recommendation.

†Individual results may vary. Important drug safety and benefits information on semaglutide (1mg/ml and 2.4mg/ml injection for subcutaneous use, an Rx only compound drug, can be found here. Semaglutide has not been FDA-approved or evaluated for safety, efficacy, or quality but can be used for weight loss. It may cause side effects including nausea, diarrhea, vomiting, and constipation. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
§The information provided here is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely upon the content provided here for specific medical advice. If you have any questions or concerns, please talk to your provider.
◊Services and treatments not offered in every state, include medical treatment of overweight and obesity including lifestyle counseling (e.g., diet and exercise) and prescription medications, if clinically appropriate, based on completion of  required consultation. Nurx requires regular check-ins to monitor your progress.  Weight loss may be associated with other symptoms including but not limited to muscle loss, fatigue, menstrual changes, gallstones, and mood changes. Extreme/rapid weight loss may result in nutritional deficiencies that lead to hair loss, anemia, weak bones or increased risk of infection. Talk to your provider immediately about symptoms. Many people with overweight or obesity who lose weight have a tendency to regain all or some of the weight over time. Overweight and obesity medication efficacy increases with the addition of diet and exercise. Individual response to treatment may vary and is not guaranteed by Nurx.
Compounded drugs are not FDA-approved or evaluated for safety, efficacy, or quality. Nurx compound drug offerings are not available to patients in California or Hawaii.

Exceptional care at every step

At Nurx, we make it easy to get the expert healthcare you deserve. From schedules to health history, everybody is different—so we provide treatment and care that’s personalized to you. Through life’s cycles, changes, and transitions, we’re here to help you make informed choices about your health.

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