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Take one tablet at the same time every single day (and no later than 3 hours from the time you took your tablet the day before). Never skip your daily tablet.

To start using Opill®:

As with any birth control method, Opill® does not prevent pregnancy all the time. Opill® will work best if you take it exactly as directed. In US clinical trials, approximately 98 out of 100 sexually active women who used Opill® for a year did not become pregnant in that time.

Opill® is a progestin-only pill (POP). Opill® contains the hormone progestin but does not contain estrogen, so it is different than the commonly used combined oral contraceptive, which contains both estrogen and progestin. Opill® works mainly by thickening your cervical mucus which helps to block sperm from getting to the egg. You must take it every day to prevent pregnancy. In addition, Opill® may prevent your ovaries from releasing eggs. Every one of the 28 tablets in your blister pack contains the active ingredient, so you must take one tablet every day with no breaks.

Most changes to periods are to be expected. Continue taking Opill® exactly as directed, even if you have the following changes in your periods:

Your periods may be less or more frequent, shorter or longer, lighter or heavier than before you started Opill®. You may also have some spotting or bleeding between periods. Some women stop having periods while taking Opill®. Take a pregnancy test or talk to a medical provider if your period is late after missing any tablets in the last month, if you have not had a period for 2 months, or if you think you may be pregnant.

Talk to a medical provider AND continue using this product every day if you experience repeated vaginal bleeding that is brought on by sex, or start having menstrual periods that last more than 8 days or are unusually heavy.

Less than 3 hours late: Don't worry. Take 1 tablet immediately and go back to taking your tablet at your usual time the following day.

More than 3 hours late OR you missed one or more tablets:

Take 1 tablet immediately, as soon as you remember.

Then, go back to taking your tablet at your usual time. This means you may take 2 tablets in 1 day. For example, if you usually take your tablet at night, but forget and remember in the morning, take 1 tablet when you remember and take 1 tablet again at the usual time that night.

You must use a condom (or another barrier method) every time you have sex during the 2 days (48 hours) after you restart Opill®, because it takes 2 days to start working again.

Take a pregnancy test or talk to a medical provider if your period is late after missing any tablets in the last month.

Talk to a medical provider or pharmacist if you are taking or are starting to take medications that treat any of the following conditions, as these may make Opill® less effective:

Seizures (barbiturates, carbamazepine, oxcarbazepine, phenytoin, topiramate, primidone)

Tuberculosis (rifampin, rifabutin)

Pulmonary hypertension (bosentan)

HIV/AIDS (efavirenz)

St John's Wort (or any herbal products containing hypericum perforatum)