What are the best birth control pills with the fewest side effects?

Choosing the right birth control goes beyond just preventing pregnancy—it’s also really important that you feel good on it! 

If you’re fed up with uncomfortable side effects you’ve experienced in the past, or you’re just hoping for a smoother experience, that’s totally valid. Most people want a pill that works with their body, not against it.

Some birth control pills are formulated with lower doses of hormones, which can reduce side effects like nausea, headaches, or mood changes. These can be a great option if you’re sensitive to hormonal shifts or just want a more comfortable day-to-day experience.

But the truth is, there’s no one-size-fits-all answer. What works well for someone else may not be the best fit for you. That’s why personalized care matters. A healthcare provider can help you explore your options, talk through any past experiences you’ve had, and find a pill that supports both your health and your lifestyle.

Types of birth control pills

Hormonal birth control pills come in two main types, each with its own benefits. Knowing the difference can help you and your provider find the option that works best for your body, lifestyle, and health history.

Some pills contain both estrogen and progestin, while others contain only progestin. Each has been designed with specific goals in mind, from reducing side effects to offering more flexibility in how you manage your reproductive health.

Your provider will consider factors like your age, whether you smoke, and any existing medical conditions when recommending a pill. If estrogen isn’t a good fit for you, there are effective options without it. What matters most is finding a method that supports your whole health—because birth control isn’t one-size-fits-all.

Combination birth control pills

Combination pills contain both estrogen (usually ethinyl estradiol) and progestin. They’re the most commonly prescribed type of birth control pill and offer a range of benefits beyond pregnancy prevention.

Most combined birth control pills come in 28-day packs with:

• 21 hormone-containing pills
• 7 inactive pills (or placebo pills) with no hormones that allow for a predictable withdrawal bleed

This regular schedule makes it easier to track your cycle and feel in control. These pills can also help with:

• Lighter periods
• Reduced cramping
• Improved acne

If you’re sensitive to hormones, low-dose combination pills like Sprintec®, Junel® Fe, or Lo Loestrin® Fe may be a good fit. These options contain lower levels of estrogen but still provide reliable protection, often with fewer side effects.

Progestin-only birth control pills (Minipills)

Progestin-only pills—sometimes called minipills—contain just one hormone: synthetic progestin. They’re a great option for people who can’t take estrogen or prefer to avoid it altogether.

These pills are often recommended for:

• Breastfeeding individuals
• Smokers over age 35
• People with health conditions that make estrogen unsafe

Unlike combined oral contraceptives, minipills must be taken at the same time every day to stay effective. They mainly work by thickening cervical mucus to prevent sperm from reaching the egg and may not always stop ovulation.

Still, when taken correctly, they offer strong protection, and because they don’t contain estrogen, they may cause fewer side effects like:

• Nausea
• Breast tenderness
• Mood changes

They’re also linked to a lower risk of blood clots, which can make them safer for people with certain risk factors.

Common side effects

When starting hormonal birth control, it’s completely normal to have questions about side effects. While many people tolerate the pill well, your body may need a little time to adjust to the hormones.

What you might notice at first

Most side effects are mild and often fade within a few weeks or months. You may experience:

• Nausea
• Breast tenderness
• Headaches
• Mood changes
• Spotting or breakthrough bleeding (especially in the first few months)
• Bloating or slight weight gain, often from water retention, not fat

Keeping track of your symptoms can help your provider know whether your current pill is a good fit or if it’s time to try something different.

Rare but serious side effects

While uncommon, some side effects require immediate medical attention. Seek in-person care right away if you experience:

• Severe leg pain or swelling
• Chest pain or trouble breathing
• Severe headaches or vision changes
• Sharp or persistent abdominal pain

If you have a history of high blood pressure or breast cancer, certain pill formulations may not be recommended. Your provider will always review your medical history to make the safest choice for you.

What to expect over time

Most side effects ease up after a few months as your body adjusts. If you’re still not feeling quite right, don’t worry. Finding the right pill often takes a bit of trial and error. The key is open communication with your provider and a willingness to make changes when needed.

Long-term risks and cancer considerations

Current research shows that while some birth control pills may slightly increase the risk of certain cancers, they actually lower the risk of ovarian and endometrial cancers. For most people, the overall cancer risk remains very low.

Plus, the protective benefits against these cancers can last for years after stopping the pill. Your provider can discuss your personal risk factors to help you make an informed choice.

Birth control pills with the fewest side effects

With lower hormone doses and more refined formulations, many pills offer effective pregnancy prevention with fewer day-to-day disruptions.

Low-dose pills

Modern low-dose combination pills typically contain fewer micrograms of estrogen compared to older versions. That lower dose may mean:

• Fewer mood swings
• Less bloating
• Minimal weight changes
• Reliable, effective contraception

By delivering just enough hormone to prevent pregnancy—without overwhelming your system—low-dose pills strike a careful balance between effectiveness and tolerability.

The following low-dose combination pills are often recommended for people looking to reduce side effects:

• Yasmin®
• Lo Loestrin® Fe
• Tri-Lo-Estarylla®

These options are designed to support hormonal balance while minimizing acne, headaches, and other common complaints.

The type of progestin used in your pill matters, too. Newer generation progestins are known for:

• Fewer androgenic effects (like acne or excess hair growth)
• Improved skin clarity in some people
• Greater tolerability overall

That’s why pills like NikkiTM, Tri-Lo-Estarylla®, and Microgestin® Fe continue to be go-to choices for long-term users who want dependable cycles, steady moods, and a low risk of unwanted effects.

Progestin-only pills

If you’ve had trouble with estrogen in the past, a progestin-only pill might be a better fit. These “minipills” contain no estrogen (just a low, consistent dose of progestin) and are especially helpful for:

• People who experience nausea, headaches, or mood shifts with combination pills
• Those over 35 who smoke
• Anyone with a history of migraines with aura or blood clot risk factors

While irregular menstrual bleeding can occur (especially during the first few months), many people find that trade-off worth it.

Other birth control methods with minimal side effects

Birth control pills are a popular choice, but they’re not the only option, and they’re not the right fit for everyone. If you’re looking for a method with fewer or different side effects, there are several alternatives that might better suit your body, lifestyle, or preferences.

Each method works a little differently, and what causes side effects for one person might work just fine for someone else. The good news? There’s a wide range of options out there, and sometimes a small switch can make a big difference.

Male and female condoms

Looking for a non-hormonal option? Male and female condoms are great choices for avoiding side effects altogether. They’re the only methods that also protect against sexually transmitted infections (STIs), which makes them a smart pick for many people.

• No hormones = no systemic side effects
• Provides protection against STIs (unlike most hormonal methods)
• Useful as a backup method or during pill transitions
• Available in latex and non-latex options

The key with barrier methods like condoms is consistent, correct use. With a little practice, many people find they can use them easily and confidently, either on their own or alongside another method.

Long-acting reversible contraceptives (LARCs)

For those wanting low-maintenance options with minimal side effects, LARCs like intrauterine devices (IUDs) and implants can be great choices. These methods deliver hormones locally or use none at all, which often means fewer systemic effects compared to daily pills.

• Hormonal IUDs (like Mirena® and Skyla®) release low doses of progestin directly in the uterus, minimizing hormone exposure elsewhere
• Copper IUDs (like Paragard®) are hormone-free, offering effective contraception without hormonal side effects
• Implants (like Nexplanon®) provide steady progestin release and require no daily action

LARCs offer convenience and long-term protection, usually for 3 to 10 years depending on the device, but can be removed anytime you decide to try for pregnancy or switch birth control methods.

Fertility awareness methods (FAM)

If you prefer non-hormonal and natural options, fertility awareness methods involve tracking your body’s signs of fertility to avoid pregnancy. This approach has no direct side effects and empowers you to understand your cycle better.

• Involves monitoring basal body temperature, cervical mucus, and cycle days
• Requires consistent daily tracking and sometimes app support
• Works best with training or guidance from a knowledgeable provider

While effectiveness varies based on user diligence, FAM can be a good fit for people seeking hormone-free birth control.

Preventing pregnancy without discomfort

Finding the right birth control pill is super personal, and sometimes, it takes time. Your body is unique, and so is the way it responds to different hormonal options.

Because of this, the whole idea of finding the best birth control pills with the least side effects is completely dependent on you. Working closely with a provider who listens and understands your needs can make all the difference here.

Whether you’re considering low-dose combination pills, progestin-only pills, or exploring alternatives, the goal is the same: to find a method that fits your life with as few side effects as possible. It’s completely normal to try a couple of options before landing on one that feels right. The important thing is having clinical guidance along the way.

At Nurx, we make that process easier. With expert support, thoughtful care, and convenient access to trusted options, we’re here to help you feel confident in your choice of contraceptive methods, every step of the way. Start your birth control journey with Nurx today.

Frequently Asked Questions (FAQ)

What is the healthiest birth control?

There’s no one-size-fits-all answer. The healthiest option depends on your health history, lifestyle, and what your body needs. Many people do well with low-dose combination pills or progestin-only pills (also called minipills), since they’re often easier on the body and come with fewer side effects, but your provider will help guide you.

What is the mildest birth control?

Progestin-only pills are usually seen to bring on fewer side effects compared to combination pills. They don’t contain estrogen, which makes them a good choice if you’re sensitive to hormonal shifts or have conditions that make estrogen a less safe choice. They can be a great starting point for people who want fewer hormonal ingredients in their birth control.

What is the least recommended birth control?

Some methods may not be the right fit depending on your health and goals. For example, birth control options that don’t align with your medical history might not be recommended. A provider will talk through your options and help you avoid anything that doesn’t support your overall well-being.

What is the best birth control for mood stability?

Many people find that low-dose options are easier emotionally—but it really depends on your body. Your provider can help you choose a method that supports your mental and emotional health, not just your reproductive goals.

The information provided is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely upon this content for medical advice. If you have any questions or concerns, please talk to a medical professional.

Services not offered in every state. Medications prescribed only if clinically appropriate, based on completion of required consultation. Individual results may vary.

Yasmin® (drospirenone and ethinyl estradiol), Rx only, is an oral contraceptive used to prevent pregnancy. This drug may cause side effects, including headaches, irregular and/or heavy uterine bleeding, dysmenorrhea, nausea and/or vomiting and back pain. If you would like to learn more, please see the full prescription information here. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch: HTTPS://WWW.FDA.GOV/SAFETY/MEDWATCH /default.htm or call 1-800-FDA-1088.

Junel Fe 1/20® (norethindrone acetate 1mg and ethinyl estradiol 0.02mg tablets, and ferrous fumarate 75mg tablets), Rx only, is an oral contraceptive used to prevent pregnancy. This drug may cause side effects, including headaches, irregular and/or heavy uterine bleeding, dysmenorrhea, nausea and/or vomiting and back pain. If you would like to learn more, please see the full prescription information here. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch: HTTPS://WWW.FDA.GOV/SAFETY/MEDWATCH /default.htm or call 1-800-FDA-1088.

Sprintec® (norgestimate and ethinyl estradiol), Rx only, is an oral contraceptive used to prevent pregnancy. This drug may cause side effects, including headaches, irregular and/or heavy uterine bleeding, dysmenorrhea, nausea and/or vomiting and back pain. If you would like to learn more, please see the full prescription information here. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch: HTTPS://WWW.FDA.GOV/SAFETY/MEDWATCH/default.htm or call 1-800-FDA-1088.

Lo Loestrin Fe® (norethindrone acetate and ethinyl estradiol tablets, ethinyl estradiol tablets and ferrous fumarate tablets), Rx only, is used as contraception to prevent pregnancy. This drug may cause side effects, including irregular uterine bleeding, nausea, breast tenderness, and headache. If you would like to learn more, see full prescribing information, here. You are encouraged to report negative side effects to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Tri-Lo-Estarylla® (norgestimate and ethinyl estradiol), Rx only, is an oral contraceptive used to prevent pregnancy. This drug may cause side effects, including headaches, irregular and/or heavy uterine bleeding, dysmenorrhea, nausea and/or vomiting and back pain. If you would like to learn more, please see the full prescription information here. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch: HTTPS://WWW.FDA.GOV/SAFETY/MEDWATCH/default.htm or call 1-800-FDA-1088.

Nikki® (drospirenone and ethinyl estradiol), Rx only, is an oral contraceptive used to prevent pregnancy. This drug may cause side effects, including headaches, irregular and/or heavy uterine bleeding, dysmenorrhea, nausea and/or vomiting and back pain. If you would like to learn more, please see the full prescription information here. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch: HTTPS://WWW.FDA.GOV/SAFETY/MEDWATCH/default.htm or call 1-800-FDA-1088.

Microgestin FE® 1/20 (norethindrone acetate/ethinyl estradiol and ferrous fumarate), Rx only, is an oral contraceptive used to prevent pregnancy. This drug may cause side effects, including headaches, irregular and/or heavy uterine bleeding, dysmenorrhea, nausea and/or vomiting and back pain. If you would like to learn more, please see the full prescription information here. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch: HTTPS://WWW.FDA.GOV/SAFETY/MEDWATCH/default.htm or call 1-800-FDA-1088.

Mirena® is not available through Nurx. Learn more about Mirena® including risks and side effects here. All product names, manufacturer or distributor names, logos, trademarks, and registered marks (“Product Marks”) are the property of their owners and are for identification purposes only. Product Marks do not imply any affiliation, endorsement, connection, or sponsorship by their owner(s) with Nurx.

Skyla® is not available through Nurx. Learn more about Skyla® including risks and side effects here. All product names, manufacturer or distributor names, logos, trademarks, and registered marks (“Product Marks”) are the property of their owners and are for identification purposes only. Product Marks do not imply any affiliation, endorsement, connection, or sponsorship by their owner(s) with Nurx.

Paragard® is not available via Nurx. Learn more at paragard.com. All product names, manufacturer or distributor names, logos, trademarks, and registered marks (“Product Marks”) are the property of their owners and are for identification purposes only. Product Marks do not imply any affiliation, endorsement, connection, or sponsorship by their owner(s) with Nurx.

Nexplanon® is not offered through Nurx. Learn more at nexplanon.com. All product names, manufacturer or distributor names, logos, trademarks, and registered marks (“Product Marks”) are the property of their owners and are for identification purposes only. Product Marks do not imply any affiliation, endorsement, connection, or sponsorship by their owner(s) with Nurx.