Your capsule is a compounded medication that includes Naltrexone HCl, Bupropion HCl, and Metformin HCl. Each of these ingredients plays a role in how it works:

Naltrexone HCl (5mg): a medication that blocks opioid receptors in the brain and can also help regulate appetite and cravings.

Bupropion HCl (50mg):  An antidepressant medication that affects norepinephrine and dopamine levels in your brain that can enhance metabolism and aid in weight loss.

Metformin HCl (250mg): A type of medicine called a biguanide  typically used for diabetes because it helps your body use insulin better and keeps blood sugar levels under control. This can also help with managing your weight.

Other Ingredients:  Microcrystalline cellulose

Do not use this medication if you:

• Are allergic to naltrexone, bupropion, or metformin
• Have uncontrolled high blood pressure
• Have a history of seizures
• Currently taking or expecting to need prescription opioid pain medications in the next three months
• Have moderate to severe liver or kidney disease
• Have history of disordered eating behaviors such as anorexia or bulimia
• Are taking a monoamine oxidase inhibitor (MAOI), citalopram, or atomoxetine
• Are pregnant or breastfeeding

Speak to your medical provider before starting Nurx 3-in-1 Pill if you have:

• Experienced mental health conditions including depression, bipolar disorder, anxiety. 
• A history of alcohol or substance use disorder
• Diabetes or prediabetes 
• Heart disease, including history of heart attack or heart failure
• Graves Disease, hyperthyroidism, or overactive thyroid
• Any other medications or supplements you take regularly

Stop using Nurx 3-in-1 Pill and notify your clinician if you experience

• Pregnancy
• Thoughts of suicide* or dying
• New or worsening depression or anxiety
• Feeling agitated or restless
• Panic attacks, increased irritability, anger, or aggression.
• Unusual behavioral changes, including impulsive actions, extreme activity levels, or excessive talking.
• Severe illness (especially with vomiting, diarrhea, dehydration, or fever)
• New or severe trouble breathing
• Unusual muscle pain
• Extreme tiredness
• Unexplained stomach pain.

Discontinue the Nurx 3-in-1 Pill if you will undergo any of the following within the next two weeks:  

• Surgical procedure  
• CT scan with IV contrast  
• Trying to conceive  

Side effects may include:

• Nausea, vomiting, or upset stomach
• Dry mouth
• Headache, dizziness, tremor
• Increased anxiety, irritability, malaise, fatigue
• Insomnia or sleep disturbances 
• Increased sweating, hot flush, or tremor
• Constipation or diarrhea
• Muscle pain/strain, joint pain
• Elevated blood pressure, palpitations
• Excessive sweating
• Rash
• Liver dysfunction 

Warnings:

• Avoid taking with a high fat meal as this can increase drug absorption and increase risk of side effects.

Storage guidance:  These tablets should be stored at controlled room temperature (68 F to 77 F / 20 C to 25 C.  Keep it in a safe place where children and pets cannot access it. Protect from moisture and direct sunlight.  

*If you’re experiencing a mental health crisis, please call 911 or  go to your nearest emergency department. If you are contemplating suicide, call 911 or call/text the National Suicide and Crisis Lifeline at 988. These services are available 24/7.

Nurx 3-in-1 Pill (Naltrexone HCl 5 mg/Bupropion HCl 50 mg/Metformin HCl 250 mg capsule), an Rx only compound drug, has not been FDA-approved or evaluated for safety, efficacy, or quality but can be used to reduce hunger and appetite and promote weight loss. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch  or call 1-800-FDA-1088.

Disclaimer: Information contained on this handout is provided as an informational aide and for reference use only. The content herein is not intended to be, act as, or replace medical advice or diagnosis for individual health conditions nor is it making evaluations as to the risks or benefits of particular compounded preparations. Please consult a licensed healthcare professional about diagnosis and treatment. Information and statements within this handout have not been evaluated by the Food and Drug Administration.