Rx
Generic Retin-A®

Tretinoin anti-aging cream .1%

4.8
26,562 Nurx Reviews
Based on all Nurx reviews, not any one product

Tretinoin is a retinoid that treats fine lines, wrinkles, and signs of premature aging.*

Anti-aging
Topical cream

$30/month

Treatment requires an online consultation with a Nurx medical provider. Medication cost may vary based on prescribed treatment for your individual needs. Medications shipped and billed quarterly. Price not guaranteed; additional costs apply, including consultation and support fee.

How tretinoin reduces signs of aging*

  • Reduces hyperpigmentation and uneven pigmentation
  • Reduces visible signs of aging
  • Reverses skin aging related to sun exposure
  • Reverses and prevents fine lines, wrinkles, age spots, and dark spots 
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DID YOU KNOW?

20x stronger

Tretinoin is 20 times stronger than over-the-counter retinols.

Real patient stories

Real results

Shannon, Nurx patient

Real results

Nathalia, Nurx patient

The science behind it

Fact 01

Increases collagen production

Tretinoin increases collagen production and speeds up the skin’s natural renewal process to reveal fresh new skin.

Fact 02

Stimulates cell growth

It stimulates cell growth and exfoliation while decreasing the buildup of dead cells that can clog pores.

Fact 03

Visible results over time

Generally, it takes 3-6 months of regular use to notice skin improvement, with best results in 6-12 months.*

How to use tretinoin 0.1%

Consistency is key to maximizing the effectiveness of your anti-aging treatment.

Drug facts

Step 1

Each night, apply a pea-sized amount evenly to clean skin and allow it to dry.

Step 2

Follow up with a layer of moisturizer.

Step 3

In the morning, apply sunscreen as tretinoin makes skin more sensitive to UV rays.

How Nurx works

1

Request treatment

Complete our online medical consultation, which asks questions about your health history and skin concerns.

2

Connect with a provider

After evaluating your consultation, a provider licensed in your state will prescribe treatment (if clinically appropriate).

3

Get it delivered

We’ll send a 3-month supply to your doorstep and check in with you to see how it’s working. Pause or cancel anytime.

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Why Nurx?

Affordable

Quality treatment at an attainable price

Convenient

Easy refills & shipping to your door

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Unlimited messaging for any questions, anytime

Common questions

  • How do I use tretinoin?

    Tretinoin should be used once daily at bedtime. To use tretinoin cream, simply wash your face with a mild facial cleanser. Make sure your skin is dry before using the product. Then, take a pea-sized amount of tretinoin and apply a thin layer to your skin. We recommend following up with a layer of moisturizer, especially if you have dry or acne-prone skin.

    Tretinoin can make your skin more sensitive to UV light. Using tretinoin at night lowers your risk of sun damage. During the daylight hours, protect your skin from sunburn and sun damage by wearing protective clothing, hats, and sunscreen with an SPF of 30 or higher.

    Avoid getting tretinoin in your eyes, ears, mouth, and nose. Tretinoin should be stored tightly closed, at room temperature, in its original container.

  • How long does tretinoin take to work?

    If you are new to tretinoin, you may experience some skin flaking and if acne prone, some blemishes after using the product for 3 to 6 weeks.This is a normal part of the skin renewal process. Don't give up! Most people see a noticeable improvement in their complexion after using tretinoin for 6 to 12 weeks.

  • How often should I use tretinoin?

    Tretinoin should be applied once daily at bedtime. It should not be used during the day as it can increase sensitivity to the sun.

  • Does tretinoin help with wrinkles?

    Because it speeds up cell turnover, tretinoin can make your skin look brighter and younger. Tretinoin also increases your skin's production of collagen, a vital component in young, healthy skin.

  • Does tretinoin have any known side effects?

    Like every topical retinoid, tretinoin use may cause side effects. Most of the side effects caused by tretinoin are mild and include redness, dryness, flaking, or peeling skin. These effects can be managed by using more moisturizer and using the medication less frequently such as every other night when first starting. You may also experience a mild, temporary stinging or warming sensation when applying tretinoin. Skin treated with tretinoin is more prone to sunburn Repeated use of tretinoin may also cause temporary lightening or darkening of the skin. Most people using tretinoin find that side effects lessen as their skin adjusts to treatment. These mild side effects generally dissipate when tretinoin is no longer used.

    Although severe reactions are uncommon, possible serious side effects include itching, hives, and pain. These side effects are usually a result of an allergic reaction. Such reactions to tretinoin are considered rare. If you are allergic to drugs that contain Vitamin A, you may be at higher risk for an allergic reaction.

  • What precautions should I take when using tretinoin?

    As with any prescription medication, discuss your medications, allergies, and treatment options with your primary care doctor or a Nurx provider before using tretinoin cream. If your skin is irritated or sunburned, you may need to allow your skin to heal before beginning treatment. Your medical provider can advise you when to add tretinoin to your skin care regimen.

    Tretinoin cream can make your skin more sensitive to ultraviolet light. Using tretinoin at night lowers your risk of sun damage. During the daylight hours, protect your skin from sunburn and sun damage by wearing protective clothing, hats, and sunscreen with an SPF of 30 or higher. Avoid spending time in tanning beds and under sunlamps. If you get sunburned or your skin becomes extremely red or blistered, stop using tretinoin cream and contact your healthcare professional immediately.

    Some tretinoin users experience new or increased sensitivity to extreme weather conditions, such as low temperatures or high winds. Wear protective clothing to stay comfortable during cold or windy weather.

    When using tretinoin, your facial cleansers and cosmetics should be gentle, non-abrasive, and non-drying. Confused about which products to use? Your Nurx provider can help you choose products that maximize the benefits of tretinoin and minimize unpleasant side effects.

    Tretinoin should not be used by patients who are pregnant, breastfeeding, or trying to conceive. If this applies to you, your provider may help you find an alternative treatment that is appropriate for you, such as Azelaic Acid.

  • Can I use tretinoin cream with other medications?

    Tretinoin is generally compatible with other medications. To prevent excessive dryness and irritation, avoid using facial cleansers, toners, and cosmetics that contain sulfur, salicylic acid, or resorcinol. Never combine tretinoin with products containing benzoyl peroxide, as they diminish tretinoin's effectiveness and can result in dryness.

    Topical products that may interact with tretinoin include perm solutions, medicated cleansers, exfoliating soaps, alpha hydroxy acid, glycolic acid, and products that contain alcohol, lime, or menthol. Using these products with tretinoin can cause excessive redness, irritation, and peeling.

  • Does tretinoin expire?

    All prescription retinoids come with an expiration date that can be found on the medication’s packaging. Although not dangerous to use, expired tretinoin may be less effective.

DR. PETER YOUNG, MEDICAL DIRECTOR

Meet your medical team

Peter Young, MD is the Medical Director for Nurx’s Dermatology specialty. Dr. Young is a board-certified dermatologist who advises the Nurx medical team on how to provide the highest quality of care for dermatology conditions through telehealth.

†Tretinoin Cream 0.1%, Rx only, treats fine lines, wrinkles, discoloration, and signs of premature aging, and may cause side effects, including drying, flaking, or peeling skin. If you would like to learn more about Tretinoin Cream, please see the full prescription information here. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.
*Individual results may vary.
‡The information provided here is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely upon the content provided here for specific medical advice. If you have any questions or concerns, please talk to your provider.
◊Services not offered in every state. Medications prescribed only if clinically appropriate, based on completion of the required consultation.

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