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How soon can people expect to see results when using tretinoin for anti-aging treatment?

Dr. Nancy Shannon

Medically reviewed by Dr. Nancy Shannon, MD, PhD on April 19, 2021

Usually it takes 3-6 months of nightly application of tretinoin to see significant improvement, however many patients cannot tolerate a retinoid every night to start out because retinoids exfoliate the top layer of the skin and can cause dryness, peeling, or irritation. Because of this patients are generally advised to start by using a prescription retinoid 2-3 nights per week and gradually increase until the skin can tolerate nightly application. Note, however, that the best (and most lasting effects) come from consistent use over the course of many years.

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