Rx
Generic Vistaril®

Hydroxyzine HCl

4.8
26,564 Nurx Reviews
Based on all Nurx reviews, not any one product

Hydroxyzine HCl is an antihistamine medication that may be prescribed to treat anxiety.

Anxiety Icon Anxiety
Pill Icon Pill

$25/month

As low as $0/month with insurance

Medication shipped and billed every 1 or 3 months.
This treatment requires an online consultation with a Nurx medical provider. Cost may vary based on your insurance coverage, price not guaranteed. Not all insurance plans are accepted. Medication costs vary based on prescribed treatment and applicable insurance coverage and are shipped and billed separately as a 1-month or 3-month supply. Additional costs apply, including a monthly medication management fee.

A person with red hair and earrings smiles softly, with a blurred green background.

How hydroxyzine HCl treats anxiety*

  • Blocks the effects of histamine
  • Makes you feel calmer and less stressed
  • Boosts serotonin to help with mood balancing
Find my treatment
Blurry image of a field with colorful wildflowers and tall trees in the background.
Did you know?

42 million US adults

have anxiety disorder

Real patient stories

The science behind it

Fact 01

Blocks histamine

Hydroxyzine HCl is an antihistamine that blocks the effects of a chemical called histamine on the body.

Fact 02

Boosts serotonin levels

This medication raises levels of serotonin in the brain to increase feelings of relaxation and calm.

Two women sit on a couch engaged in conversation, with one smiling. A large plant is in the background.
A person with red hair and freckles looks thoughtfully to the side, wearing a white shirt and earrings, with sunlight on their face.

How to use hydroxyzine HCl

If you are using this medicine to help with anxiety before stressful events, it’s a good idea to try it beforehand to see how quickly it works for you.

Drug facts

STEP 1

Take as prescribed by your provider.

STEP 2

May be taken with or without food.

STEP 3

Depending on your level of anxiety and how you respond to treatment, your provider may recommend adjusting your dosage.

How Nurx works

1

Request treatment

Complete our online medical consultation, which asks questions about your health history and mental health symptoms.

2

Connect with a provider

After evaluating your consultation, a provider licensed in your state will prescribe treatment (if clinically appropriate).

3

Get it delivered

We’ll send a 1 or 3-month supply to your doorstep and check in with you to see how it’s working. Pause or cancel anytime.

A blurred image of a natural landscape with indistinct trees and vegetation.

100%

online care

2+ million

Nurx patients served

A person wearing headphones and a beige sweater holds a smartphone with a floral case, glancing at an article on Tretinoin Cream.
Why Nurx?

Affordable

Quality treatment at an attainable price

Convenient

Easy refills & shipping to your door

Personalized

Providers help you find the right treatment

Supportive

Unlimited messaging for any questions, anytime

Common questions

  • What is hydroxyzine HCl?

    Hydroxyzine HCl is a prescription medication used to treat anxiety, allergies, and pruritus (itching). Hydroxyzine HCl is an effective short-term treatment for generalized anxiety disorder. It’s a member of a drug class called antihistamines. It works by blocking certain effects of histamine in your body. This can result in helping you feel more calm or relaxed. Hydroxyzine HCl can also help relieve itching due to certain skin conditions.

  • How does hydroxyzine HCl work?

    Hydroxyzine HCl works by making you feel calmer and less stressed. It’s an antihistamine that prevents histamine from exerting its effect on the body. Hydroxyzine HCl also boosts serotonin levels in your brain. This helps with mood balancing and an overall sense of well-being. It also can help your muscles relax, causing less tension.

  • What are the side effects of hydroxyzine HCl?

    Common side effects of hydroxyzine HCl include headache, constipation, dry mouth, and drowsiness. Some side effects may be more severe than others and require immediate medical attention. It’s best to speak with your provider if you notice any unusual symptoms during treatment with hydroxyzine.

  • How do I take hydroxyzine HCl?

    Hydroxyzine HCl is usually taken orally three or four times a day as needed. A typical dose for adults is between 50 to 100 mg up to four times a day. Take as directed by your provider.

  • Can I take hydroxyzine HCl with other medications?

    Hydroxyzine HCl can be taken with other medications, but you should inform your provider if you are taking other medications. Some medications may cause interactions when taken with hydroxyzine HCl, including narcotics, other antihistamines, some antidepressants, and barbiturates.

  • Are there any risks when taking hydroxyzine HCl?

    Hydroxyzine HCl can cause drowsiness or dizziness in some people, so it’s best to avoid driving or operating heavy machinery. Also, make sure to tell your provider if you are taking other medications or if you have a prolonged QT interval or glaucoma. Taking this medication can be risky for women who are breastfeeding or pregnant, so tell your provider if you are breastfeeding, currently pregnant, or plan to become pregnant.

  • How quickly does hydroxyzine HCl work?

    Hydroxyzine HCl is a fast-acting medication for anxiety and starts working more quickly than some other medications, such as SSRIs. You may notice improvements in anxiety symptoms within one hour of taking your first dose. Most people will feel its maximum effect at around 2 hours.

Please note: Nurx does not provide therapy or counseling. Nurx is not available for crisis response. If you are experiencing a mental health crisis, please contact 911 or go to your nearest emergency department. IF YOU ARE CONTEMPLATING SUICIDE, CONTACT 911 OR CALL/TEXT THE NATIONAL SUICIDE PREVENTION LINE AT 988. These services are available 24/7.

A person with tied-back hair and a light-colored jacket smiles against a plain background.
DR. GABRIELLA FARKAS, MEDICAL DIRECTOR

Meet your medical team

Gabriella Farkas, MD PhD is the Medical Director for Nurx’s mental health services. Dr. Farkas is a board-certified psychiatrist who advises the Nurx medical team on how to provide the highest quality of care for mental health conditions through telehealth.

†Hydroxyzine HCL (10mg) and Hydroxyzine pamoate (25mg), Rx only, treats anxiety. This drug may cause side effects, including but not limited to drowsiness, dizziness, dry mouth. If you would like to learn more, see full prescribing information, here. You are encouraged to report negative side effects to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. If you’re experiencing a mental health crisis, please call 911 or go to your nearest emergency department.
*Individual results may vary.
‡The information provided here is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely upon the content provided here for specific medical advice. If you have any questions or concerns, please talk to your provider.
◊Nurx does not provide talk therapy or crisis management. Services not offered in every state. Medications prescribed only if clinically appropriate, based on completion of the required consultation.

Talk to our providers

Not sure if this medication is right for you?

Connect with a Nurx provider for a personalized treatment recommendation.

Exceptional care at every step

At Nurx, we make it easy to get the expert healthcare you deserve. From schedules to health history, everybody is different—so we provide treatment and care that’s personalized to you. Through life’s cycles, changes, and transitions, we’re here to help you make informed choices about your health.

Hand holding a smartphone displaying a conversation about birth control pill concerns between a user and Dr. Nancy Shannon on the Nurx app.
Back to top