As with all birth control pills, serious, though unlikely, side effects have been recorded in patients who are taking TriNessa. You should speak with your doctor immediately if these side effects appear. TriNessa can increase your risk of blood clots, hypertension, migraines, eye problems, depression, and liver problems. If you have hyperlipidemia, you should monitor your condition closely while taking TriNessa because this pill may elevate your lipid levels. This pill may increase your risk for breast, uterine, or ovarian cancer. Check regularly for breast lumps, and talk to your doctor if you experience any new or unusual abdominal pain.