Product details

If you regularly experience migraines and are tired of over-the-counter migraine medication that simply doesn’t work, it may be time to consider Pamelor. We at Nurx™ take great pride in offering our patients a variety of options to make their lives more enjoyable, and preventing migraines is an important part of living a pain-free life. Pamelor is a great option for migraine prevention and as an added bonus can even help elevate your mood and decrease depression and anxiety thanks to its antidepressant properties.

Pamelor is a type of antidepressant medication that’s known as a tricyclic antidepressant, or TCA. TCAs work by directly affecting certain neurotransmitters in the brain that are responsible for your mood. The neurotransmitters that TCAs impact include serotonin and norepinephrine. These chemicals can also impact how we experience pain, making this medication an option when looking to prevent migraines. Pamelor is available in generic form under the name Nortriptyline.

If you currently take a monoamine oxidase inhibitor (MAOI) such as Parnate, Marplan, or Nardil, Pamelor is not for you. Our experts can help you find a different migraine prevention medication that’s perfectly suited to your needs and won’t interact with the medications you’re currently taking.

Pamelor and its generic version, Nortriptyline, are manufactured by Mallinckrodt Pharmaceuticals.

Additional Details

  • Treats depression
  • Migraine prevention
  • Treats anxiety
  • Helps balance chemicals in the brain responsible for elevated moods
  • May promote smoking cessation
  • Treats panic disorders
  • Treats post-herpetic neuralgia
Active Ingredients
  • Nortriptyline hydrochloride USP
  • Do not take Pamelor if you have used an MAO inhibitor, such as Linezolid, Selegiline, or Isocarboxazid, in the last 14 days.
  • Do not take Pamelor if you are allergic to its ingredients or are allergic to similar antidepressants such as Doxepin, Desipramine, or Amoxapine.
  • Do not take Pamelor if you are allergic to seizure medications such as Oxcarbazepine or Rufinamide.
  • Do not take Pamelor if you are pregnant or breastfeeding.
  • Inform your doctor if you experience symptoms of angle-closure glaucoma (a condition in which fluid in the eye becomes blocked is unable to flow out of the eye, resulting in a severe increase of eye pressure that could lead to vision loss).
  • Do not drink alcohol or use narcotics unless prescribed while on Pamelor.
  • Combining Pamelor with other TCAs (tricyclic antidepressants) may result in constipation.
  • Taking Pamelor with Clonidine may result in a dangerous elevation in blood pressure.





  • How Is Pamelor Used?

    Pamelor is a capsule that's taken daily. You should choose a certain time each day to take this medication and take it at the same time each day to maximize its effectiveness. You will likely start on a low dose of Pamelor and slowly increase the dose based on how effective it is at preventing migraines. Some people may need to take Pamelor three to four times a day at a lower dose, while others may take Pamelor once a day at a higher dose. Our team at Nurx can help you decide the best option for you when it comes to your daily dose of Pamelor.

    Pamelor is available in several different dosages: 10 mg, 25 mg, 50 mg, and 75 mg. It's important to not stop using Pamelor suddenly, as withdrawal symptoms can occur. These withdrawal symptoms aren't life-threatening but can certainly be unpleasant, and we at Nurx don't want you to feel anything less than amazing while taking your medication. Store Pamelor in a dry and cool place at room temperature.

  • Is Pamelor Easy to Get?

    Pamelor is a fairly popular antidepressant medication that's widely available in pharmacies. It does require a doctor's prescription, but not to worry. At Nurx, our doctors create a personalized migraine treatment plan based on your needs and provide a prescription online. We generally prescribe the generic version of Pamelor, Nortriptyline, which can be sent to you in the mail or filled at your local pharmacy.

    We accept several different insurances, and we're constantly working to expand this list. Even if Pamelor isn't covered by your insurance or if you choose not to use your insurance provider to pay for Nortriptyline, we will help you find an affordable option so you can get the migraine prevention solution you need.

  • What Precautions Should I Take Before Starting Pamelor?

    As with any new medication, you should consult with your doctor or one of our trusted medical professionals before you begin taking Pamelor. Our doctors can help you decide if Pamelor is the right option for you and if you're at risk for an allergic reaction to this medication. But, overall, allergic reactions to Pamelor are fairly low.

    If you are currently taking a MOAI or have taken a MOAI in the last 14 days, you should not take Pamelor. If you are on a MOAI, we at Nurx can help you find another migraine prevention option that's right for you.

    Occasionally, Pamelor may increase the risk of suicidal thoughts or behaviors in individuals ages 24 and younger. If you're younger than 24, keep track of your mood while taking Pamelor, especially when you first start taking it. If you start to experience suicidal thoughts, let your doctor know immediately.

    If you have urinary or HI retention, hyperthyroidism, cardiovascular disease, diabetes, liver or kidney impairment, a seizure disorder, or bipolar disorder, let your doctor know before beginning Pamelor. This medication can sometimes exacerbate these conditions.

  • Are There Any Potential Side Effects?

    As with nearly any medication, Pamelor comes with the potential for side effects. Fortunately, most side effects associated with this medication are mild and will typically go away once your body becomes used to the drug. Common side effects that may occur when taking Pamelor include nausea, tiredness, anxiety, dry mouth, nightmares, constipation, changes in weight or appetite, changes in sex drive, frequent urination, and excessive sweating.

    Serious side effects are rare but have been documented. These more severe side effects include rash, hives, hepatitis, seizures, muscle spasms, fever, irregular heartbeat, and trouble swallowing or breathing. If you experience any of these symptoms, speak with your doctor as soon as possible.

    While these symptoms may sound scary, it's important to remember that they are very uncommon, and the positive benefits almost always outweigh any side effects for people struggling with migraines. Plus, Pamelor can help not only prevent migraines, but can also improve your overall mood, which is a win-win in our book.

  • Can I Take Pamelor With Other Medications?

    Generally, yes, Pamelor can be taken with most other medications. However, it should not be taken with MAOIs. Pamelor may also not pair well with certain other antidepressants, including those in the tricyclic antidepressant family. Other medications that may not pair well with Pamelor include:













    It's very important to tell your doctor or one of our Nurx professionals about all medications you currently take, including recreational drugs, herbal supplements, and over-the-counter medications before starting this medication.

  • Can I Buy Pamelor Online Through Nurx?

    Yes! Nurx offers the generic version of Pamelor, Nortriptyline. You can work with one of the many doctors who are part of the Nurx team to determine the most appropriate dosage for you. We can then mail your prescription if you prefer the privacy and discretion, or you can fill the prescription at your local pharmacy.

  • Does Pamelor Cause Weight Gain?

    Tricyclic antidepressants like Pamelor can potentially cause weight gain. However, everyone is different and will respond differently to this medication. One person may gain weight while taking Pamelor while another person may not notice any weight differences while on this drug. If you're concerned about gaining weight while taking Pamelor, a great way to prevent weight gain would be to have a good diet and exercise plan in place that you'll follow while taking this medication.

  • Does Pamelor Make You Tired?

    Tiredness is a potential side effect of Pamelor, so there is a chance this drug may make you sleepy while you take it. Luckily, you can cope with this easily by simply choosing to take this medication at night before bed rather than during the day. This should counteract any tiredness the medication makes you feel and can even result in a better night's sleep.

  • How Does Nurx Work?

    Nurx is a telehealth platform offering easy online access to doctors and seamless delivery of medications. No more time-consuming trips to the clinic and no more frantic pharmacy runs. We put you in control of your own health, empowering you to get the care you need, when you need it. From diagnosis to delivery of prescriptions, we make every part of getting healthy and staying healthy, better.For more information and to signup, visit and follow us @nurxapp on Twitter and Instagram.

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